Why is it important to choose your Mastodon home wisely? Because "You can move your user account from one instance to another, but you have to follow a special procedure which can be quite long... create another account on a new instance and import three lists... your followers, ... the accounts you have blocked [and] have muted".
[note: Carl wrote this in 2017, when there were "more than 1.5 million users on more than 2350 existing instances"].
Key issues to look for:
Like many I tried to use the https://instances.social tool to choose mine, but the one I eventually chose (someone I knew was there) wasn't even listed there.
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See also: Fediverse (Overview)